Goofs

• Continuity: In the near end of the film, while Peter Parker/Spider-Man is on top of the large crane, he is in a prone position; and we see a rip in his outfit along the top part of his left thigh. Moments later, the camera re-cuts back to him, and the rip is now on his right thigh.
• Continuity: When Peter jumps across the table to save Mary Jane from the car coming through the window, her chair falls over as he grabs her. In the next shot we see him lift her out of her chair without toppling it.
• Continuity: The wheels on the car Doc Ock throws through the cafe window are spinning as it flies over Peter and Mary Jane. But when it lands moments later, the wheels are stationary.
• Revealing mistakes: When Peter is talking with Aunt May while she's loading boxes out of the house, you can see the shape and bulge of his microphone and wire under his shirt.
• Audio/visual unsynchronized: When we first see Aunt May in the movie, she's speaking while kissing Peter but her lips are not moving.
• Continuity: When Dr. Ock walks out of the hospital and flips the taxi that's coming toward him, the oncoming traffic changes between shots. You can see that the car is going to land on its hood in the middle of the street and there are no cars parked, yet in the next close-up shot, it lands on its wheels and over a parked taxi, pointed on the wrong way.
• Continuity: When Henry - the little boy helping Aunt May pack ? says, "Hi" to Peter, he is standing by the driveway, yet in the next shot when Peter tells him "You're getting tall", they both are standing several feet away, right in front of the garage door. The same switch takes place when Aunt May tells Peter "Everybody loves a hero".
• Continuity: When Spider-Man is trying to stop the train, the font left window of the first car shatter, we can see that the handrails are on each side of the door, (pointing toward each other). The next shot shows the suit on his left arm ripping, and then the handrails are now pointing forward. A couple of shots later, when the right window shatters, the handrails are again pointing toward each other.
• Revealing mistakes: Peter is able to hold the metal door knob in the burning building. By then the knob would have been very hot.
• Continuity: When Doc Ock is kidnapping MJ, Doc Ock climbs up a building and one tentacle hits a sign which falls down. A few shots later when Peter is his glasses on and off, the sign is back up.

Trivias

• Sam Raimi officially signed on to direct on 1 April 2002, more than a month before the first film opened.
• For a scene featuring fighting on the exterior of a subway train amidst a crowd of skyscrapers, portions of this film were filmed in Chicago, Illinois, on the famous elevated Loop standing in for New York City's 9th St. El in Manhattan, torn down in 1940, with routes transferred to underground subway lines. Chicago El trains were made up to appear as R-train cars, complete with MTA New York City Subway decals and "Bay Ridge" on their destination boards, even though the shots of the buildings are those of Lexington Avenue - including the balcony bridge that connects parts of Hunter College - where the 4, 5, and 6 trains run.
• Filming began before an official script was completed.
• Robert De Niro, Sam Neill, Ed Harris, and Chris Cooper were all considered for the role of Otto Octavius.
• Tobey Maguire's participation was in doubt at one point because he was suffering severe back pains. Jake Gyllenhaal, was lined up to play Spider-Man and had already begun preparation, but Maguire decided to take part after all. However, according to the DVD commentary, the "My back!" joke after Peter falls from the roof was purely coincidental, as it was written into the script before Maguire's problem arose.
• 35 Spider-Man costumes were used during the filming.
• Many of the shots with Spider-Man web slinging were made identical to the first Spider-Man cartoon TV series, aired in 1967. This is especially apparent during the final slinging scene, where Spider-Man swings off the screen in like manner to the way the he did at the end of every episode of the show's first season.
• The bank used in this film where Spidey and Ock have the big fight scene, was the same bank used in "Police Academy 6: City Under Siege".
• Danny Elfman, who did the film score (and for several others by Sam Rami) had some sort of falling out with the director during the course of this film, and has been quoted saying "To see such a profound negative change in a human being was almost enough to make me feel like I didn't want to make films an ymore." He has stated that they'll never work together again.
• The battle with Doctor Octopus and Spider-Man along the side of a building is a homage to an episode of the 1967 Spider-Man TV show episode, "The Terrible Triumph of Doctor Octopus."